Evaluation of Some Clinical Chemistry Parameters of Wistar Rats Induced with Staphylococcus aureus from Clinically Diagnosed Pneumonia Patients

Authors: Enwa FO*, Jemikalajah JD, Adjekuko C and Ogbare CB

DOI: 10.23880/oajpr-16000225

Volume 5, Issue 1

Abstract

The effect and extent of changes in some clinical chemistry parameters associated with pneumonia caused by Staphylococcus aureus were investigated in serum samples of Wistar rats. A total of 1500 samples were collected randomly. The serum samples were tested for sodium, potassium, urea, creatinine and chloride by colorimetric methods. The concentrations of sodium ranged from 133.6±4.615 to 143.8±6.906, potassium values ranged from 5.78±1.26 to 8.02±0.779, urea gave a range of 10.143±0.69 to 14.444±2.404, chloride values ranged from 94.8±2.683 to 104.142±8.49, while creatinine values ranged from 0.489±0.033 to 1.7±2.404. The results indicated that staphylococcus aureus has a significant effect on the electrolyte balance causing hyperkalemia and decreased levels of sodium and chloride when compared with the normal range. It had a remarkable effect on creatinine level with only slight effect on urea. There is need to monitor the electrolyte levels in cases of staphylococcus aureus infection since alteration in the electrolyte levels could be harmful to health.

Keywords: Clinical Chemistry Parameters; Staphylococcus Aureus; Wistar Rats; Pneumonia Patients

View PDF