Efficacy and Safety of Piperacillin-Tazobactam: Systematic Review and Metaanalysis

Authors: Rosanova Maria Teresa*, Bes David, Sberna Norma, Herrera Ramos Estefanía and Lede Roberto

Volume 5, Issue 1

Abstract

Introduction: Piperacillin-tazobactam (PTZ), although contested, is frequently utilized for empirical treatment of Gramnegative bacteria treatment. Objective: Systematic review to evaluate if PTZ is associated with lower rates of treatment failure and less adverse effects than other comparators. Material and Methods: Literature search in Embase, and MEDLINE databases using “piperacillin tazobactam” as leading term. A study qualified, when a properly randomized control trial (RCT) compared the efficacy and safety of PTZ with other antibacterial agents in an “intention to treat analysis” of clinically evaluable patients. Results: Eleven studies fulfilled inclusion criteria. Pooled RR of failure risk rate was 25% less using PTZ than other comparators (0.75; CI 95% 0.59-0.95). Adverse effects were similar. Conclusions: PTZ can be adequately considered for empirical treatment of patients with Gram-negative bacteria infections

Keywords: Piperacillin-Tazobactan; Efficacy; Bacterial Infections; Safety; Gram Negative; Empiric Therapy; Systematic Review; Failure

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