Clinical Pathology & Research Journal (CPRJ)
ISSN: 2642-6145
Research Article
Doppler Ultrasound in Prostate Cancer: It’s Utility for the
Diagnosis of High-Grade Tumors
Authors:
Marcos Álvares de Campos
,
Lucas Mendonça Darwich
,
André Thomaz Ezequiel Pereira
,
Viviane Fernandes de Castro Rodrigues
,
Renato Alves Carvalho
,
Elisa Carvalho de Siqueira*
,
Fabrício Tinoco Alvim de Souza
,
Fabiano Franco Monteiro Prado
,
Tiago Paes Gomide
,
Paulo Ramos Botelho Antunes
,
Maria Carolina Barbosa Álvares
and
Luiz Felipe de Campos-Lobato
DOI:
10.23880/cprj-16000130
Abstract
Purpose: The aim of the present study was to evaluate the association between prostate vascularization seen in Doppler ultrasound and histopathological grade (Gleason score) in patients with a diagnosis of prostate cancer.
Methods: A Gleason score >7 was the dependent variable and Doppler ultrasound findings (vascular analysis, presence of nodule and prostate weight) were the independent variables. Univariate analysis was performed considering advanced tumors (Gleason >7) as the dependent variable and area of hypervascularization, age and PSA as the independent variables. Multivariate analysis was performed using a binary regression model with the occurrence of advanced tumors (Gleason >7) as the dependent variable.
Results: In the univariate analysis, samples with Gleason \(\le 7\) had a lower chance of being hypervascularized (OR: 0.44, 95% CI: 0.29-0.69), whereas those with Gleason scores >7 had a fourfold greater chance of being hypervascularized (OR: 4.136, 95% CI: 2.598-6.554, p<0.001). Moreover, hypervascularized tumors had a 7.4-fold greater chance of having a score >7.
Conclusion: The present study reveals an association between tumor hypervascularization detected using Doppler ultrasound and higher Gleason scores (more aggressive tumors), enabling an indirect inference of a worse prognosis for hypervascularized prostatic tumors. These findings should be confirmed in longitudinal studies.
Keywords: Prostate cancer; Gleason Hypervascularization; Doppler; Prostate carcinoma; Ultrasonography; Biopsy
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