ISSN: 2642-6145
Authors: Marcos Álvares de Campos, Lucas Mendonça Darwich, André Thomaz Ezequiel Pereira, Viviane Fernandes de Castro Rodrigues, Renato Alves Carvalho, Elisa Carvalho de Siqueira*, Fabrício Tinoco Alvim de Souza, Fabiano Franco Monteiro Prado, Tiago Paes Gomide, Paulo Ramos Botelho Antunes, Maria Carolina Barbosa Álvares and Luiz Felipe de Campos-Lobato
Purpose: The aim of the present study was to evaluate the association between prostate vascularization seen in Doppler ultrasound and histopathological grade (Gleason score) in patients with a diagnosis of prostate cancer. Methods: A Gleason score >7 was the dependent variable and Doppler ultrasound findings (vascular analysis, presence of nodule and prostate weight) were the independent variables. Univariate analysis was performed considering advanced tumors (Gleason >7) as the dependent variable and area of hypervascularization, age and PSA as the independent variables. Multivariate analysis was performed using a binary regression model with the occurrence of advanced tumors (Gleason >7) as the dependent variable. Results: In the univariate analysis, samples with Gleason ≤7 had a lower chance of being hypervascularized (OR: 0.44, 95% CI: 0.29-0.69), whereas those with Gleason scores >7 had a fourfold greater chance of being hypervascularized (OR: 4.136, 95% CI: 2.598-6.554, p<0.001). Moreover, hypervascularized tumors had a 7.4-fold greater chance of having a score >7. Conclusion: The present study reveals an association between tumor hypervascularization detected using Doppler ultrasound and higher Gleason scores (more aggressive tumors), enabling an indirect inference of a worse prognosis for hypervascularized prostatic tumors. These findings should be confirmed in longitudinal studies.
Keywords: Prostate cancer; Gleason Hypervascularization; Doppler; Prostate carcinoma; Ultrasonography; Biopsy
