Evolution of Antibiotic Resistance in Enterobacter Spp Isolated at the Yaounde University Teaching Hospital from January 2008 to November 2019

Authors: Kamga HG*, Nzukui N, Lyonga Mbamyah Emilia, Tchuedji YGN, Betbeui AC, Noubom M, Boum IIY and Arthur E

DOI: 10.23880/oajmb-16000191

Volume 6, Issue 2

Abstract

Purpose: A study was conducted to evaluate the evolution of the resistance of Enterobacter spp to antibiotics during twelve years and to update the data. Method: A retro-prospective study was carried from January 2008 to November 2019. Data was extracted from the registers of the bacteriology laboratory and the strains from samples received from the different units of the YUTH. The study of the antibiotic resistance profile of these species and phenotypic analysis was carried out by the method of discs diffusion in Mueller-Hinton agar. Phenotypic characterization was carried out by synergy test and modified Hodge test. Findings: A total of 109 strains were isolated in our study. Enterobacter species showed high resistance with a peak in 2012 for cephalosporins, in 2011 for aminoglycosides, in 2018 for quinolones, in 2019 for carbapenems with the frequencies of 80%, 45%, 37% and 36,1% respectively. These species exhibited 30% resistance to colistin. The resistance peak to the majority of antibiotics between 2018 and 2019 reflects an increase of resistance. The Extended Spectrum - Lactamases (ESBL) phenotype was the most represented with frequency of 32.4%. Unique contribution to theory, practice and policy: To Update the data on the evolution of Enterobacter spp, which will help to establish a surveillance strategy in Cameroonand adapt an adequate treatment regimen.

Keywords: Evolution; Enterobacter Spp; Phenotypes; Esbls; Antibiotic Resistance

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