ISSN: 2642-1143
Authors: Lijun C, Wang X, Wenxin S, Huifang Z, Juanxia C, Chao C, Yanhong L and Xiaoyong M*
Objective: 1) to investigate the expression level and significance of HIF-1 α in COPD stable period, AECOPD and healthy people; 2) to explore the change and significance of HIF-1α expression level at all levels in AECOPD patients; 3) to analyze the relationship between HIF-1α and FEV1%, Hs-CRP, PO2, dioxygen in AECOPD patients. The correlation of carbon partial pressure (PCO2) and the role of HIF-1α in the progression of AECOPD were discussed. Methods: 180 COPD patients (120 in acute exacerbation stage and 60 in stable stage) from May 2016 to January 2017 in the outpatient or inpatient department of the First People›s Hospital of Yinchuan City were collected, and 60 healthy controls of the same age were enzymatically linked immunosorbent assay (ELISA) to detect the level of HIF-1α in blood, lung function, serum high-sensitivity C-reactive protein, and serum hypersensitivity C-reactive protein. The arterial partial pressure (PO2) and partial pressure of carbon dioxide (PCO2) were measured by arterial blood gas analysis, and their differences and correlation were analyzed. Results: 1. The levels of HIF-1α and Hs-CRP in AECOPD group, COPD stable group and healthy control group were significantly different (P < 0.05). 2. The levels of HIF-1α and Hs-CRP in each grade of AECOPD group increased with the increase of grade, the difference was statistically significant (P < 0.05). 3. In AECOPD group, FEV1% was negatively correlated with HIF-1α, Hs- CRP and PCO2 (p < 0.05), but positively correlated with PO2 (r = 0.425, P < 0.05). 4. In AECOPD group, HIF-1α was positively correlated with Hs-CRP (r=0.209, P<0.05), HIF-1α was negatively correlated with PO2 (r=-0.198, p<0.05), and HIF-1α was not correlated with PCO2 (r=0.152, p>0.05). Conclusion: 1. The level of HIF-1α in AECOPD group and COPD group increased significantly, and the level of HIF-1a increased with the grade of AECOPD. 2. HIF-1a is closely related to FEV1%, Hs-CRP and PO2 in patients with AECOPD, and can reflect the hypoxia and inflammation in patients with AECOPD.
Keywords: COPD; HIF-1alpha; Hypoxia; Inflammation
