Recombinant Interferon-Alpha 2b for Ocular Surface Squamous Neoplasia (OSSN)

Authors: Kadir SMU*

Volume 6, Issue 1

Abstract

Ocular surface squamous neoplasia (OSSN) is an ambit of ocular surface diseases encompassing dysplasia to different grades of invasive squamous cell carcinoma of the ocular surface. The typical presentation is the leukoplakic appearance with feeder vessels of conjunctiva, limbus, and cornea. Histological confirmation after incisional/excisional biopsy has been considered the gold standard for OSSN. 5-fluorouracil (5-FU) and mitomycin C (MMC) has used as adjuvant topical chemotherapy. Recently, interferon-alpha 2b (INF α2b) is operating as immunotherapy for the treatment of OSSN. Good outcome with fewer side effects than other drugs are reported. An overview on INF α2b for the treatment of OSSN is attempting to analyze mode of action, dose and duration, and treatment modality and outcome of INF α2b.

Keywords: Ocular Surface Squamous Neoplasia; Vernal Keratoconjunctivitis; Interferon Alpha; Glycoprotein; Recombinant DNA

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