Journal of Infectious Diseases & Travel Medicine (JIDTM)

ISSN: 2640-2653

Case Report

Sub-Acute Interstitial Pneumonia – First Clinical Indicator of Underlying Immune Compromise Due to HIV Infection

Authors: Vinay V, Dinesh K, Pushkar K, Paras V and Amit S*

DOI: 10.23880/jidtm-16000149

Abstract

Background: The significant number of late presenters of human immunodeficiency virus (HIV) infection remains a serious public health problem. Late presenters [CD4 cell count below 350 cells/ mm3 or with an acquired immune deficiency syndrome (AIDS)-defining event regardless of the CD4 cell count] are associated with a significant risk not only for AIDSdefining conditions but also for non AIDS-defining diseases which aggravate the prognosis of patients. Lymphoid interstitial pneumonitis (LIP) is one of these conditions described more often after the onset of HIV epidemic. LIP is a benign polyclonal lymphoproliferative disorder of the lung with not well characterized clinical and radiographic findings. Case presentation: We report the uncommon case of LIP as an initial presentation of HIV. The findings of computed tomography indicated the diagnosis of HIV-associated LIP, although this condition is mainly described in a normal range of CD4 cell count. Conclusion: It is important to recognize HIV as one of the risk factors for LIP with antiretroviral therapy resulting in rapid improvement of HIV-associated LIP. This case presentation highlights the importance of timely diagnosis and initiation of antiretroviral therapy. The increase of CD4 cell count and viral suppression may improve the symptoms of LIP.

Keywords: HIV; Lymphoproliferative; Sub-acute Interstitial; Pneumonia

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