Molecular Mimetism Phenomenon in SARS Cov-2

Authors: Gomez JF*, Delgado JT, Florez BB, Zedan VG and Florez JB

DOI: 10.23880/mjccs-16000S1-012

Special Issue 1

Abstract

Background: Following the current SARS Cov2 pandemic, cross-reactivity was proposed as a mechanism that could explain the immunopathology associated with coronavirus infection. The rationale is that the exchange of peptide motifs between SARS Cov2 and human proteins could elicit immune responses capable of attacking not only the virus but also human proteins with the consequent autoimmune pathological sequelae in the human host. Methodology: A mini narrative review was carried out through various databases from October 2020 to January 2021; the search and selection of articles was carried out in journals indexed in English and Spanish. The following keywords were used: Molecular mimicry, SARS-CoV-2, Covid-19. Results: There is solid evidence that shows the existence of a link between SARS Cov2 infection and autoimmunity induced by the phenomenon of molecular mimicry. Conclusions: This review offers information based on the available evidence about the phenomenon of molecular mimicry in SARS Cov2.

Keywords: Molecular mimicry; SARS CoV 2; Covid-19

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