Acute Myeloid Leukemia with BCR-ABL1 Translocation: A Rare Entity

Authors: Jamal I*

Volume 5, Issue 2

Abstract

Acute myeloid leukemia (AML) with BCR-ABL1 is a provisional entity in WHO classification of hematological malignancies and it is a denovo AML in which patients show no evidence of Chronic myeloid leukemia (CML) [1]. It accounts for <1 % of all AMLs and it primarily occurs in adults with male predominance [2]. Patients present with leucocytosis with blast predominance along with anemia and thrombocytopenia. Compared with CML patients less frequently splenomegaly and lower peripheral blood basophilia [3]. Morphological features include presence of peripheral blood and bone marrow myeloblasts showing minimal differentiation to granulocytic maturation. Average bone marrow cellularity is less than CML and dwarf megakaryocytes are also less common.

Keywords: Leukemia; Hematological Malignancies; Translocation

View PDF