Medicinal Chemistry of Curcumin and its Therapeutic Approaches from Ancient Medicine to Recent Potential

Authors: Raut V* and Bhandari S

DOI: 10.23880/oajpr-16000244

Volume 5, Issue 3

Abstract

Many natural medicinal plants have been utilised to cure a range of disorders since ancient times and are regarded as a possible source of phytochemicals for the creation of new medications. One of these is curcumin, a bioactive molecule that is easily available, affordable, and harmless. It is a vital, naturally occurring, highly lipophilic and phenolic chemical. Curcumin (diferuloylmethane), a low-molecular-weight chemical derived from the roots of Curcuma longa L. (family Zingiberaceae), is mostly used as a curry spice, flavouring agent, insect repellant, food colouring agent, traditional medication, and cosmetic component. Curcumin is a tautomeric molecule that exists in organic solvents as an enolic form and in water as a keto form.Though inconclusive, epidemiological findings show that turmeric intake may lessen the incidence of some malignancies and provide other beneficial biological benefits in people. Turmeric’s biological benefits have been linked to its ingredient curcumin, which has been extensively researched for its anti-inflammatory, anti-ulcer, anti-diabetic, anti-viral, antioxidant, wound healing, and anti-cancer properties. Curcumin is a low-toxicity nutraceutical that has been utilised successfully in a variety of medical ailments, as discussed in this article.

Keywords: Curcumin; Pharmacological Activities; Turmeric; Structure Activity Relationship; Molecular Targets

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