ISSN: 2642-6129
Authors: Rajasekaran E*
Carbon plays an important role bio-molecular structure and function. Carbon distribution is responsible for bio-molecular association. This carbon distribution in proteins has been part of our activities in the last 15 years. It has been carried out from sequence to structure level. It required hydrogen atom added to the structure for analysis and all. Here the similar observations from carbon coordinates obtained from X-ray structure are reported. The carbon distance from nearest carbon is focus of this work. The distance is computed for a set of carbon atoms present in a particular spherical dia. The distances are grouped based on its values which are ranging from 2.1 to 3.1with group interval of 0.1. This distance distributed over different groups are analysed for presence of active site, order, disorder, carbon-rich and poor-carbon regions. The results are able to locate these sites as well as identify amino acids that need to be mutated for stability and function. The results are in agreement with other predictions obtained from sequence and all atom analysis. This distance distribution analysis gives guidance on how important the carbon distribution in these biological systems and to deal further with liveable material in the future to come globally or universally.
Keywords: Optimum Carbon; Carbon Distribution; Carbon Domain; Proteomics; Crystal
