ISSN: 2642-6145
Authors: Raghav S, Sen AK, Bhutani N, Chauhan DS, Bhardwaj M and Gupta AK
Introduction: Breast cancer is the second most common cancer in the world and, by far, now the most common cancer in women in India. It becomes important to recognize benign lesions, both to distinguish them from in situ and invasive breast cancer and to assess a patient’s risk of developing breast cancer, so that the most appropriate treatment can be given. Material and methods: The present study was a cross sectional observational study, conducted on breast tissue specimens received in the department of Pathology, P.G.I.M.E.R & Dr. R.M.L Hospital, New Delhi, in collaboration with the Department of Surgery, from the period of 1st November 2013 to 31st March 2015. The sample size for this study was 80. Histological assessment was done and Immunohistochemistry was applied on all the cases using P-caherin antibody. Results: Out of a total of 40 benign cases, 100% cases showed positive staining with P Cadherin. Whereas for 40 malignant cases studied, 24 cases (60%) showed no staining. The staining index for them was zero. 7 cases (17.5%) showed staining index between1-3. A comparison of P cadherin positivity was done between all benign and malignant cases. The association between the type of lesion of the breast and result of IHC staining is considered to be statistically significant. Conclusion: P-cadherin is a highly sensitive marker for myoepithelial cells. Its expression strongly correlates with the type of breast lesion, which can help in differentiation between benign and malignant lesions whenever there is confusion in diagnosis with routine methods.
Keywords: Breast carcinoma; Fibroadenoma; Immunohistochemistry; Myoepithelial Cell; P- Cadherin
