Risk Factors and Incidence Rates of Adverse Covid-19 Vaccines Reactions: a Longitudinal Study of 109 Adverse Reactions Cases from February to September 2021 in General Medicine of Toledo (Spain)

Authors: Turabian JL*

DOI: 10.23880/eij-16000219

Volume 6, Issue 1

Abstract

Background: Information on the safety of vaccines against COVID-19 is essential. Objective: To describing the incidence rates (IR) and risk factors for adverse COVID-19 vaccines reactions in general medicine. Methodology: An observational, longitudinal and prospective study of patients que consuln por adverse reactions to COVID-19 vaccines in a general medicine office in Toledo (Spain) was carried out from February to September 2021. Results: We found an IR of 5% cases of adverse COVID-19 vaccines reactions in people = <14 years x 8 months, the highest figure being between 14-49 years, in women, and with Pfizer-BioNTech-BNT162b2 and AstraZeneca-ChAdOx1 nCoV- 19 vaccines. Regarding gravity, the highest IR was 3 cases of moderate adverse COVID-19 vaccines reactions per 100 COVID-19 vaccines x 8 months. Statistically significant protective factors were: > = 65 years, 14-49 years, or 14-18 years, male, some type of labour specialization, complex family, and chronic diseases of Circulatory system; and risk factors: age 14-65 years, female, chronic diseases of Endocrine, and Nervous and Senses. Vaccine Moderna- mRNA-1273 was the only one that showed a protective Relative Risk of of adverse COVID-19 vaccines reactions, but without statistical significance. Conclusion: In the context of general medicine in Toledo (Spain), during the 8-month follow-up, the IR of adverse COVID-19 vaccines reactions is low. The risk estimates clearly favour vaccination.

Keywords: COVID-19; SARS-CoV-2; Adverse Drug Events; Post-vaccination Reactions; Vaccine Safety, COVID-19 vaccine; General Practice; Epidemiology; Risk Factors

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