ISSN: 2642-6250
Authors: He Q*, Wu J, Zhu L, Wang H and Han Y
This article aims to summarize the current research on the influence of physical activity-induced changes in myocytokine secreted by skeletal muscle cells on Alzheimer's disease (AD). Alzheimer's disease is the most common neurodegenerative disease leading to dementia. The limited clinical effect of current drug therapy, and there is no effective treatment strategy to treat, reverse or slow down the progression leading to an irreversible course. Physical activity (PA) is any physical exercise produced by skeletal muscles that requires energy consumption. Research shows that moderate physical activity is beneficial to health, and more evidence supports the beneficial effects of PA on neurodegenerative diseases such as AD, Mild cognitive impairment, and Dementia. This article reviewed the current research progress on the influence of changes in myocytokine expression induced by physical activity on AD, which would lay the foundation for further exploration of the mechanism of physical activity to improve cognition and prevent AD in the elderly.
Keywords: Alzheimer's Disease; Physical Activity; Myocytokines; Brain Derived Neurotrophic Factors
