Evaluation of the Relationship between Angiotensin 2 Converting Enzyme (ACE2) and the Occurrence of Acute Renal Impairment (AKI) In Patients with COVID-19

Authors: Esfandiari F, Hassanpour M, Azmoon R, Kor S and Ahmadi A*

DOI: 10.23880/aabsc-16000177

Volume 5, Issue 1

Abstract

COVID-19 is a contagious disease caused by the SARSCOV-2 virus and was first reported in Wuhan, China in December 2019. ACE2 is a membrane-width protein that converts angiotensin 2 to angiotensin 7-1 [1,2]. This enzyme is widely present in the cell membranes of the lungs, liver, kidneys, heart, and gastrointestinal tract, and various studies have shown that the virus enters cells through ACE2. Based on the study of related articles, the results show that acute renal injury with several different mechanisms is possible in people with Covid-19 [3-6]. One of the pathways through ACE2 is called the direct pathway, where this enzyme is present on the podocytes and the apical membrane of the cells of the nearby twisted tube, and the virus attacks the podocytes and the nearby twisted tube through ACE2 and causes damage. Acute nephrons and kidney damage. Hyponatremia is the most common electrolyte disorder with multiple causes and is associated not only with pneumonia but also with gastrointestinal (GIT) symptoms.

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