Utilization of Insight in Cumulus Cells Function in the Context of Oocytes Growth, Maturation, Ovulation and Fertilization for the Enhancement of Success Rates in ART by Better Quality Oocytes and Embryos Selection- A Systematic Review

Authors: Kulvinder Kochar Kaur* , Allahbadia G and Singh M

DOI: 10.23880/oajg-16000231

Volume 7, Issue 1

Abstract

Cumulus cells (CC) get initiated from the granulosa cells (GCs) that are undifferentiated, which differentiate into mural GCs (MGCs) as well as CCs at the time of antrum generation in the follicles by the allocation of residence. CCs represent cells that are supporting cells with regards to oocytes from the milieu, that aids in oocytes growth as well as maturation in the follicles. There is existence of bidirectional connections amongst oocytes with the idea of acquiring maturation as well as embryonic generational competence subsequent to fertilization. The surges of gonadotrophins (FSH as well as LH), result in generation of extracellular matrix (ECM) in CCs, with CCs going via cumulus expansion for aiding in meiosis getting resumed. Here we conducted a systematic review utilizing search engine pubmed, google scholar; web of science; embase; Cochrane review library utilizing the MeSH terms like; CC; oocyte maturation; GCs; mural granulosa cells (MGCs); cumulus oocyte complex (COC); zona pellucid(ZP); gap junctions; meiotic maturation of the oocyte; hyaluronic acid (HA); oocyte liberated factors (OLF); BMP15; GDF9; & their downstream targets-HAS2; PGST;GERM1; SMAD2/3; Bone morphogenetic protein receptor typeII (BMPR II); PIA3K/ AKT pathway; cAMP; cGMP; epidermal growth factor receptor(EGFR), ERK1/2;IGF; pentraxin3(PTX3); cumulus expansion; VCAN; connexin 37[Cx37&Cx43; Tsg6; inter-α inhibitor protein); ADAMTS1&MMP2; apoptotic genes (survivin); proapoptotic (caspase3&7) from 1990 to 2022 till date. We found a total of 150 articles out of which we selected 115 articles for this review. No meta-analysis was done. Thus the ultimate function of CCs is that they are implicated in the finishing of oocytes meiotic maturation along with ovulation, fertilization along with following embryonic generational competence besides pregnancy. Hence getting insight in the function of CCs at the time of follicular generation might aid in anticipation of oocytes quality followed by embryonic generational competence iin addition to pregnancy results along with field of assisted reproductive technology (ARTs) for the therapy of infertility.

Keywords: Cumulus Cells (CC); Cumulus Expansion; Oocyte Quality; Pregnancy

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