ISSN: 2574-7797
Authors: Sreelakshmi AG, Thomas N, Carla B and Sunil C*
The present study evaluated the antihyperlipidemic and antibacterial activities of B. courtallensis extract. The antihyperlipidemic effect of B. courtallensis methanol extract was studied in Triton WR-1339 and high fat diet–induced hyperlipidemic rats. In Triton WR-1339 and high fat diet-induced hyperlipidemic rats, B. courtallensis (200 and 400 mg/kg) exerted a significant (P ≤ 0.05, P ≤ 0.01, P ≤ 0.001) alteration in serum levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) to near normal. The antibacterial activity of B. courtallensis was evaluated by agar-well diffusion method against selected gram negative bacteria: Bacillus subtilis, Pseudomonas aeruginosa and gram positive bacteria: Staphylococcus aureus, Escherichia coli. B. Courtallensis extract exhibited pronounced activity against all the bacterial strains tested and the activity was comparable to the standard drug Amoxicillin (100 µg/ml). The results of the present study demonstrate that the methanolic extract of B. courtallensis possess antihyperlipidemic and antibacterial activities
Keywords: Hyperlipidemia; antibacterial; B. courtallensis; Fenofibrate; Amoxicillin; Triton WR-1339
