Current Trends in Design and Development of Nanopharmaceutical Dosage Forms

Authors:

Panda BP, Patnaik S and Maharana RL

DOI: 10.23880/beba-16000104

Volume 1, Issue 1

Abstract

Nanopharmaceuticals or Nanopharmaceutical dosage forms pertaining to design of pharmaceuticals using nanotechnology based science are intended to develop various pharmaceutical dosage forms and carrier systems in the range of 10 to 1,000 nm. Nanopharmaceuticals offer novel reformulation opportunities in development of nanoscale pharmaceutical dosage forms, for delivering of many common therapeutic agents which produce challenges in the formulation of dosage form because of its low solubility, poor bioavailability, lack of specific site targeting or toxicity issues. Nanopharmaceutical dosage forms examples are solid lipid nanoparticles, polymeric nanoparticles, pegylated nanostructures, nanocrystals, dendrimers, nanotubes, nanofibers, nanomicelles, nanoshells, magnetic nanopharmaceuticals, metallic nanoparticles, nanosized powders, nanoemulsions and nanosuspensions. These nanopharmaceutical dosage forms are able to accommodate the active therapeutic moiety and bio-molecules such as enzymes, vaccines, recombinant proteins, peptides, and nucleic acid for their delivery. These dosage systems have ability to improve specific targeting either passively or actively, to a particular tissue or organ of the body where they are needed. The prime objective of this review article is to provide concise overview on nanopharmaceutical dosage forms and their potential applications as carrier systems in the delivery of therapeutic agent

Keywords:

Nanopharmaceutical dosage forms; Nanopharmaceutical carrier systems; Delivery and targeting of therapeutic agent

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