Circulating Megakaryocytes in Peripheral Blood: A Clue to Satisfactory Platelet Recovery Post Induction Chemotherapy in Acute Myeloid Leukemia

Authors: Tapas Kanti Parida , Srijita Mandal , Akshatha Nayak , Sonali Mohapatra and Somanath Padhi

DOI: 10.23880/hij-16000198

Volume 6, Issue 1

Abstract

Thrombocytopenia is a common hematological abnormality in newly diagnosed acute myeloid leukemia (AML) which may be linked to the degree of marrow infiltration by leukemic blasts as well as altered cytokine milieu in a subset of AMLs. We report the presence of circulating megakaryocytes in peripheral blood as a sign of satisfactory platelet recovery post induction chemotherapy in a pediatric subject with a favourable risk WHO category I AML with synchronous extramedullary myeloid cell tumor; and present a brief review of literature on the role of platelet recovery in AML prognosis.

Keywords: Platelet recovery; Induction; Chemotherapy; Prognosis; AML

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