ISSN: 2577-4360
Authors: Oguazu CE*, Ezeonu FC, Ubaoji KI, Enemali MO and Dike CC
Background Objective: Bisphenol A (BPA) is an endocrine disrupting chemical used on a wide range in the industry. Studies on BPA suggests that both low and high doses of BPA affects plasma hormone levels There is increasing evidence that exposure to BPA, impair normal thyroid function, reduced bound circulating and tissue thyroid hormones but the effect of BPA varies at different levels of the thyroid system. The present study aims to investigate the effect of BPA on the thyroid gland of female rats. Materials and Methods: The rats received a daily oral administration of BPA (0.05 – 1.0 mg/kg for 13 weeks). Thyroid stimulating hormone (TSH), Thyroxine (T4) and Triiodithyroxine (T3) were assayed using Autochemical analyser and data obtained were subjected to statistical analysis with the SPSS software. Results: It was found that BPA at the eleven studied doses induced a significant increase in the thyroxin stimulating hormone (TSH), free thyroxin (FT4), total thyroxin (TT4) level, while the bound thyroxin is low compared to the control. The free triiodothyroxine (FT3) and total triiodothyroxine (TT3) were initially low at group 1 but at the other doses it were on the increase. The bound triidothyroxine are lower when compared to that of the control throughout the studied time intervals. Conclusion: These results suggest that BPA has thyroid toxic effects which are mediated by the oxidative stress resulting from the overproduction of free radicals, BPA may also participate in the thyroid gland function disturbances.
Keywords: Bisphenol A; Thyroid Gland; Thyroid Stimulating Hormone; Thyroxine (T4); Triiodithyroxine (T3); Free Thyroxine (FT4); Free Triiodithyroxine (FT3); Bound Thyroxine; Bound Triiodithyroxine
