An Update on the Innovative Part of NLRP3 Inflammasome Regarding Newer Strategies for Treatment of Reproductive Conditions Possessing Greater Risk: A Systematic Review

Authors: Kaur KK*, Allahbadia GNK and Singh M

DOI: 10.23880/oajg-16000237

Volume 7, Issue 3

Abstract

Earlier we reviewed the role of NOD –like receptor protein (NLRP3) inflammasome in different patients presenting with various metabolic disorders is type 2 Diabetes mellitus obesity, Metabolic Syndrome (MetS), non-alcoholic fatty liver disease subjects NAFLD, non-alcoholic steatohepatitis (NASH). Thus Here we conducted a systematic review utilizing search engine PubMed, google scholar ;web of science; embase; Cochrane review library utilizing the MeSH terms like NLRP3 inflammasome; mode of action; recurrent spontaneous abortions (RSA); Gestational Diabetes mellitus(GDM); endometriosis; preterm birth; Polycystic ovary syndrome (PCOS); preeclampsia ;leaky gut;IL-1β;IL-18;caspase 1. We found a total of 150 articles out of which we selected 100 articles for this review. No meta-analysis was done. Here we have detailed the mechanism of action of NLRP3 inflammasome, their part in RSA, PCOS, GDM, PE, preterm birth, ovarian aging and newer non hormonal therapy for endometriosis& other practical applications.

Keywords: NLRP3 Inflammasome; Recurrent Spontaneous Abortions (RSA); Gestational Diabetes Mellitus (GDM); Preeclampsia; Leaky Gut; IL-1β; IL-18; Caspase 1; Preeclampsia; Ovarianaging

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