ISSN: 2578-4641
Authors: Hryntsova NB*
The article presents the results of the study on morphological rearrangements of structural changes in the rat pineal gland under the influence of heavy metal salts and correction with L-tocopherol during 60 days. General morphological and statistical research methods were used (histological, morphometric, immunohistochemical and statistical methods). The article presents the results of the study on morphological rearrangements of structural changes in the rat pineal gland under the influence of heavy metal salts and correction with L-tocopherol during 60 days. General morphological and statistical research methods were used (histological, morphometric and statistic methods). The protective effect of L-tocopherol caused a number of compensatory-adaptive processes in the pineal gland aimed at neutralizing the effects of stressors on the organ. Under the influence of α-tocopherol acetate, the tension on the part of the synthetic apparatus of pinealocytes decreases compared to the indicators of animals that did not use the corrector drug. The 60-days protective period of L-tocopherol is insufficient to completely neutralize the heavy metals impact on the organ: the glial response activated, the vascular area increased, vascular wall’s permeability impaired, edema was formed and the connective tissue component grew, indicating dysfunctional reorganization of the gland’s secretory activity. The above morphological changes in the pineal gland’s structural components negatively affect the processes of hormones evacuation into the blood, the course of the general adaptation syndrome and homeostasis restoration in the organ.
Keywords: Pineal Gland; General Adaptation Syndrome; Indolamines; Hypoxia
