Comparison of Cardiovascular, Analgesic and Sedative Effects of Different Doses of Dezocine

Authors:

Chang-Ming Wang¹, Zhan-Ying Guan², Chang-Hua Cai¹, Jing Zhang¹,Quan Cai Wang³, Yi Ma³ and Ping Zhao^4*

Volume 2, Issue 1

Abstract

Background: Dezocine is considered to be an alternative medication for managing postoperative pain. However, no study is focused on the cardiovascular, analgesic and sedative effects of intravenous Dezocine during anesthesia recovery period after micro vascular decompression (MVD) surgery for hemi facial spasm (HS).Therefore; we provide the clinical practice on this topic. Methods: A total of 160 patients, American Society of Anesthesiologists (ASA) physical status I–II, undergoing elective MVD surgery for HS, were randomized equally into four groups. The four groups were given intravenously a matching placebo (group A) (equal volume of 0.9% saline), Dezocine 0.05 mg/kg (group B), 0.1 mg/kg (group C) and 0.2 mg/kg (group D) respectively. Mean arterial pressure (MAP) and heart rate (HR) were measured at three periods: 5minutes before anesthesia induction (T0), at the moment of pulling out laryngeal mask (LMA) (T1),10 minutes after the procedure(T2).Sedation-Agitation Scale (SAS) at T1, Visual Analogue Scale (VAS) and Modified Observers Assessment of Alertness/Sedation Scale (OAA/S)at T2 were assessed in four groups. Mean while, the incidences of respiratory depression (RD), postoperative nausea and vomiting (PONV) were also observed during anesthesia recovery period in four groups. Multivariate analysis of variance and the Pearson χ2 test were used, and a value of P< 0.05 was considered statistically significant.

Results: The mean value of anesthesia recovery time was higher in group D (P

Conclusions: The results of current study suggests that Dezocine can effectively prevent the abrupt rise of blood pressure and HR, enhance analgesia and sedation without RD during anesthesia recovery period after MVD surgery for HS. However, Dezocine is dose-dependent in prolonging anesthesia recovery time and increasing he incidence of PONV.

Keywords:

Dezocine; Cardiovascular; Analgesic; Sedative

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