ISSN: 2574-7797
Authors: Amala FK, Boby JG *, Jeny S, Vinod B and Sunil C
Current article is focused on recent advances in the formulation and characterization of Self Emulsifying Nanoemulsions in Drug Delivery. Self-Emulsifying Drug Delivery Systems (SEDDS) are the isotropic mixtures of oil, surfactant, co surfactant and drug that form oil in water Nanoemulsion when introduced into aqueous phase under gentle agitation. Nanoemulsions are novel drug delivery systems consisting of emulsified oil and water systems with mean droplet diameters ranging from 50 to 1000 nm. Usually, the average droplet size is between 100 and 500 nm and can exist as oilin-water (o/w) or water-in-oil (w/o) form, where the core of the particle is either oil or water, respectively. A lot of techniques are available for enhancing absorption of poorly water-soluble drugs. One such approach is the use of lipidbased systems. Thus enhancement of aqueous solubility in such case is a valuable goal to successfully formulate them into bioavailable dosage forms. Nanoemulsions can be prepared by high- and low-energy methods. Both high-energy and low energy methods can produce stable Nanoemulsions. Nanoemulsion can be formulated for delivery of drugs through various routes. Nanoemulsions are well tolerated orally and on the skin and mucous membranes when used to deliver topically active drugs. Nanoemulsion globules can fuse with membranes of lipid-containing organisms facilitating penetration and transfer. Less amount of surfactant is required in Nanoemulsions compared to other emulsion systems. This can increase the bioavailability of poorly soluble drugs since small particles easily cross the absorption membrane. Furthermore, very small size provides large surface area which eases the solubilization and penetration through the skin or epithelial layer.
Keywords: Nanoemulsions; Solubilization; Nanosuspensions; Nanoparticles
