The Molecular Profile of the Urothelial Carcinoma of the Prostate

Authors: Cosma AA, Ceausu AR*, Gaje NP, Barb A, Nastase VN, Mederle OA and Raica M

DOI: 10.23880/oajun-16000221

Volume 8, Issue 1

Abstract

A 59-year-old-man presented with haematuria and dysuria. Concerning the pathological diagnostic a common problem was in this case to differentiate between high-grade urothelial carcinoma and high-grade prostate adenocarcinoma. The following immunohistochemical profile was found: keratin 7+, keratin 8/18 +; keratin 20+; AE1/AE3+; Ki 67+; p53+; S100-; chromogranin A-; vimentin -; PSA-. The molecular profile was a key element for establishing a correct therapeutic approach.

Keywords: Prostatic Urothelial Carcinoma; High-Grade Prostate Adenocarcinoma; Molecular Profile

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