Assessment of the Effects of Antiretroviral Medications on Kidney Status in Rwanda

Authors: Mugabo C and Ndikubwimana I

DOI: 10.23880/act-16000257

Volume 8, Issue 1

Abstract

According to the previous research, ART over different durations of time has an effect on the nephron as well as on liver hepatoxicity by inducing toxicity. Renal dysfunction by ART has been associated primarily with tenofovir disoproxil, which is actively accumulated in the proximal renal tubule. CKD is the major problem in ART patients and can lead to loss of kidney function, leading to complications and kidney failure, and development of cardiovascular disease. The main objectives of this study was to assess the effect of antiretroviral drugs on kidney function among the patients attended Nyanza DH during the period of two years. The research is retrospective study done to identify the effect of antiretroviral drugs on kidney Status in Nyanza DH. In total, 755 patients received the antiretroviral medications in Nyanza DH during a period of two years from the 1st of January 2015 to the 31st of December 2017. However 98 patients had data complying with the objective of this study. Those patients with kidney tests conducted every 6months, with elevated CD4 count, and eliminated viral charge. Furthermore nephrotoxicity incidence was considered for both higher concentration of Serum creatinine and lower creatinine Clearance.

Keywords: Antiretroviral Medications; Kidney; Nephrotoxicity

View PDF