Virology & Immunology Journal (VIJ)
ISSN: 2577-4379
Commentary
Methodological Considerations for Design of Studies Investigating
Gender Differences in COVID-19 Mortality
Abstract
Clinical [1], genetic [2] and epidemiologic [3] literature is increasing exponentially with papers on possible association between sex-related differences in ACE2 activity and higher mortality in men versus women with COVID-19. Surprisingly, a balanced holistic approach is lacking in published reports, contemporary clinical trials, registered clinical trials, metaanalyses and review papers.
Keywords: COVID-19; ACE2 Activity; Demographic Variables; Mortality Rate; Causal Mediation Analyses; Lifestyle Modes
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