Methodological Considerations for Design of Studies Investigating Gender Differences in COVID-19 Mortality

Authors: Rastmanesh R*

DOI: 10.23880/vij-16000310

Volume 7, Issue 1

Abstract

Clinical [1], genetic [2] and epidemiologic [3] literature is increasing exponentially with papers on possible association between sex-related differences in ACE2 activity and higher mortality in men versus women with COVID-19. Surprisingly, a balanced holistic approach is lacking in published reports, contemporary clinical trials, registered clinical trials, metaanalyses and review papers.

Keywords: COVID-19; ACE2 Activity; Demographic Variables; Mortality Rate; Causal Mediation Analyses; Lifestyle Modes

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