Development of Regression Analysis for Determination of Irbesartan in Pharmaceutical Tablets using Fourier Transform Infrared Spectrophotometry

Authors:

Khalid AA¹, AbuSeada HH¹, Mohammed WN¹ and Adel MA²*

DOI: 10.23880/macij-16000104

Volume 1, Issue 1

Abstract

A simple, cost-effective, fast and non-destructive analytical method was developed for the quantification of irbesartan in tablets using Fourier Transform Infrared (FT-IR) spectroscopy. The FTIR quantification of irbesartan in tablets was performed using two chemometric approaches, partial least squares (PLS) and principal component regression (PCR) methods. To compare the predictive ability of these models, the standard errors of prediction (SEP) were calculated. SEP error values in the range of 0.941–1.62% for calibration and validation data sets were obtained for the twoprocedures applied. A successful quantification of irbesartan in tablets containing 150 mg active ingredient/tablet was performed using the PLS model, with good recovery. The proposed procedure can be a fast, precise and convenient method of irbesartan quantification in commercial tablets.

Keywords:

FTIR Spectroscopy; Irbesartan; Angiotensin Receptor Antagonists; Chemometric Methods; Drug Analysis

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