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"Sasaki YF" ×
ACT Research Article Jun 24, 2026
Evaluation of Skin Aging Preventive Effects of Cherry Blossom Petal Extracts Through Antioxidant and Anti-Glycation Activities
Kawaguchi S*, Tabata C, Sasaki YF and Nakamura T

Skin aging progresses due to factors such as aging and UV exposure, with oxidative stress and glycation stress being known to be important contributing factors. Reactive oxygen sp…

Skin Aging Glycation Antioxidant
ACT Research Article Jan 15, 2025
Comparative Investigation of In Vitro Induction of DNA Damage and Micronuclei by Pro-Mutagens in Human-Derived Hepatoma HepG2 Cells
Kawaguchi S, Okutani S, Yamamoto A, Nakamura T and Sasaki YF*

It is important to know whether the DNA initial lesions are repaired or derive into chromosome aberration, gene mutation and/or cell death to discuss chemical carcinogenicity. To k…

HepG2 Cells Comet Assay Micronuclei
ACT Research Article May 31, 2024
Suppression of Hyperglycemia-Induced Insulin Resistance by Rapanone Isolated from Connarus Ruber
Kawaguchi S*, Kimura Y, Tsuruta T, Nakamura T and Sasaki YF

Although it would be ideal if insulin resistance due to a persistent hyperglycemic state could be prevented by consuming particular foods, to the best of our knowledge, no foods wi…

Insulin Resistance Hyperglycemia Rapanone
ACT Research Article Mar 11, 2024
How do Heterocyclic Amines, Amino Acid Pyrolysates, Inhibit DNA Repair
Kobayashi R, Sekishita A, Nakamura T, Kawaguchi S and Sasaki YF*

Heterocyclic amines (HCAs) and β-carbolines, carcinogenic substances, are produced when amino acids and creatine in food react in a high-temperature environment. Some of them are r…

Mycotoxins Probiotic Biotransformation
ACT Research Article Dec 1, 2021
Is Genotoxicity of Peroxisome Proliferator-Activated Receptor Agonists Due to Oxidative Stress Via Agonistic Pathways?
Kojima H, Nakamura T, Matsumoto K, Hasegawa A, Saito T, Sato K, Honma T, Yamamoto A, Arai H, Kadoma Y, Kawaguchi S, Kikuchi Y and Sasaki YF*

In order to investigate the relationship between genotoxicity and peroxisome proliferator-activated receptor (PPAR) agonistic effects, we conducted two kinds of comet assays (cell…

PPAR Agonist PPAR Antagonist Genotoxicity