Abstract

Induced pluripotent stem cells (iPSCs) have attracted widespread attention in the field of bone tissue engineering in recent years due to their unique self-renewal ability and multi-directional differentiation potential. Bone tissue engineering, as an important component of regenerative medicine, aims to repair and reconstruct damaged bone tissue to address clinical issues such as bone defects and fractures. Currently, research on iPSCs has shown significant potential in bone regeneration; however, there are still many challenges in their application, such as cell differentiation efficiency, immune rejection reactions, and ethical issues. This article reviews the current application status of iPSCs in bone tissue engineering, including their sources, differentiation mechanisms, and roles in bone regeneration, and discusses comparisons with other cell sources. By analyzing the latest research findings, this article aims to provide new perspectives on the potential and future development directions of iPSCs in clinical applications, promoting research and practice in bone tissue engineering.