Abstract

Introduction: Chronic kidney disease (CKD) is a public health problem with high prevalence and morbidity and mortality, associated with metabolic and cardiovascular complications and an inexorable progression to end-stage renal failure. The search for complementary therapies within natural and traditional medicine that modulate kidney damage has motivated the study of ozone therapy as a nephroprotective intervention. Objective: To describe the therapeutic effects demonstrated in scientific research on the protective effect of ozone therapy in patients with CKD, analyzing the pathophysiological mechanisms involved, preclinical and clinical results, as well as limitations and future perspectives. Method: A comprehensive search was conducted in biomedical databases, selecting relevant experimental studies and clinical trials published up to 2025. Article selection was carried out in two phases: review of titles and abstracts, followed by a complete reading of the selected texts. Data on study design, population, intervention, variables evaluated, main results, and methodological limitations were extracted. The quality of the studies was assessed using the Jadad scale for clinical trials and the ARRIVE guideline for preclinical studies. Results: Evidence indicates that ozone therapy exerts anti-inflammatory, antioxidant, and immunomodulatory effects and improves kidney function, reducing markers of damage and CKD progression with few adverse effects. However, questions remain regarding protocol standardization and extrapolation to diverse populations. Conclusions: Ozone therapy may be considered for use in the treatment of chronic kidney disease.