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International Journal of Surgery & Surgical Techniques

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Zheng Yu Wang

Zheng Yu Wang

Editorial Board Member
UAB School of Medicine USA Member since 2017

Biography

Dr. Wang is an immunologist with clinical expertise in Autoimmune Disease, and research expertise in Molecular & Cellular immunity, Xenoimmunity, and Xenotransplantation Our long-term goal of xenotransplantation research is to develop genetically modified pigs with lowly crossing the species barrier, and apply for clinical organ xenotransplantation of pig organs to humans. The strategies to prevent xeno graft rejection need to identify the targets of human antibodies and reduce xentogeneic T cell response on pig organs. My current research focuses on identifying human antibody-mediated target antigens on pig kidney/liver/skin cells using CRISPR/cas 9 gene editing including Carbohydrate xenoantigens, SLA class I and Class II, developing a novel strategy for inducing human T cell tolerance to pig xenotransplantation to humans, and understanding the mechanisms by porcine liver sinusoidal cells to phagocytose human platelets thereby alleviating the lethal thrombocytopenia observed after pig liver xenotransplantation, as well as characterizing RBC from gene-editing pigs for pig-to-primate xenotransfuion . In summary, my experience and expertise in the field of immunology and xenoimmunology have prepared me to succeed in the current project about xenotransplantation research.

Research Interests

Xenoimmunology Xenotransplantation Xenotransfuion Immunology Transplantation.

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