Utilization of Tandem Oxyanionic Cyclization/Claisen Rearrangement Strategies for the Construction of Seven and Eight-Membered Carbocyclic Ring Systems

Authors: Ovaska TV*

DOI: 10.23880/macij-16000178

Volume 7, Issue 1

Abstract

This article describes the development of microwave-assisted oxyanionic 5-exo-dig cyclization-Claisen rearrangement sequence as a convenient “one-pot” route to a variety of seven- and eight membered carbocyclic ring systems. This process was used as the key transformation for the construction of several natural products, including frondosins A, B, and C.

Keywords: Claisen Rearrangement; Sigmatropic Rearrangement; 5-Exo-Dig Cyclization; 6-Exo-Dig Cyclization; Oxyanionic Cyclization; Microwave-Assisted Synthesis

View PDF