Aspirin Loaded Niosomes A Novel Drug Delivery System by Ether Injection Method

Authors: Krishna Sailaja A* and Ruth John C

DOI: 10.23880/nnoa-16000237

Volume 8, Issue 3

Abstract

Acetylsalicylic acid (ASA), generally known as aspirin, is a nonsteroidal anti-inflammatory medication (NSAID) used to treat inflammation, fever, and pain. It also has an anti-platelet action, which lowers blood clotting by reducing platelet levels and preventing heart attacks. Aspirin's common gastrointestinal side effects are stomach ulcers and bleeding. Niosomes are vesicular drug delivery system that can enhance therapeutic efficacy and minimise side effects by encapsulating aspirin into vesicles. In this study, niosomes were prepared by the ether injection method, and a total of six formulations were prepared and evaluated, of which N2 showed 98.9% drug content and 80.8% entrapment efficiency. In vitro drug release was performed, and N4 showed 45.5% drug release at 3rd hour.

Keywords: Aspirin; Niosomes; Ether injection method; Novel drug delivery system

View PDF