ISSN: 2642-6145
Authors: Agrawal P, Ahmad S*, Agrawal N and Sengar NS
Background: In 2015, India had 69.2 million diabetes and 36.5 million impaired Glucose Tolerance (IGT) people (20-79yrs) which are expected to rise to 123.5 million and 63.6 million by 2040 respectively. Therefore need for assessing correct glycemic status of patients of Diabetes Mellitus as well as Diabetes Mellitus patients with CKD at correct time becomes necessary. Use of Fructosamine for the analysis of blood glucose levels might give better, comparatively fast results in these patients. Aims: The purpose of this study was to find out the correlation between Fasting Blood sugar, Fructosamine and HbA1c( Glycosylated haemoglobin) in patients of Type 2 Diabetes Mellitus with and without kidney disease Method: A total of 100 patients were taken and divided into 2 groups: Group A (n=50) – Patients with Diabetes Mellitus and Group B (n=50)- Patients with Diabetes Mellitus and Chronic Kidney Disease. 50 healthy controls (without DM and CKD) were taken. Result: Mean value of Fasting blood glucose in Group A – 186mg/dL SD- 52.2; Group B-182mg/dL, SD - 49.4. (t=0.781, p=0.437).The patients with DM and CKD (Group B) had lower levels of mean HbA1c (6.93%) as compared to Group A (DM), mean HbA1c -8.4%.There was significant difference between the groups (t=5.396, p<0.001). The mean of Fructosamine in Group A-439, SD-127 , Group B-421,SD-112.(t=0.757,p=0.451).Our study also showed that in different stages of CKD ,there was no statistical difference between Fructosamine and HbA1c (HbA1c Vs GFR: r= - 0, 038, p=0.817, Fructosamine Vs GFR :r= -0.057, p=0.726). Conclusion: Serum Fructosamine is superior to HbA1c in assessing blood glucose control in Diabetes Mellitus patients with CKD.
Keywords: Diabetes Mellitus; Chronic Kidney Disease; Fasting Blood Sugar; Hba1c; Fructosamine
