Macrophage Polarization in Tissue Inflammation and Fibrosis

Authors: Anto Sam Crosslee Louis Sam Titus

DOI: 10.23880/cprj-16000175

Volume 7, Issue 1

Abstract

Macrophages are mononuclear phagocytic cells, which have varied phenotypes and perform diverse intricate functions ranging from inflammation to their role in onset and progression of fibrotic diseases. After development and differentiation of myeloid progenitor cells in the bone marrow, monocytes are released into the bloodstream and these monocytes infiltrate into tissue during inflammation and mediate tissue repair.

Keywords: Macrophages; Inflammation; Tissue fibrosis

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