Association of Cytomegalo Virus and Epstein-Barr Virus with Systemic Lupus Erythematosus

Authors: Karthikeyan M*, Ashok G and Ranjith MS

Volume 2, Issue 10

Abstract

Background and Objectives: In recent decades, many research groups have focused on the role of viral infection in the etiopathogenesis of Systemic lupus erythematosus (SLE). The main candidates are Herpes virus such as Cytomegalovirus (CMV) and Epstein Barr virus (EBV). In India on this aspect is limited. Therefore it is aimed to study the involvement of Cytomegalovirus and Epstein Barr virus among the SLE patients from this part of country. Methods: Serum samples were collected from the SLE patients and subjected to Enzyme linked Immunosorbent Assay (ELISA) for the detection of CMV IgM antibody. The samples were also tested for the presence of EBV IgM antibody. Result and Conclusion: Out of 92 SLE cases tested by CMV IgM assay, 27 (29.3%) samples were found to be positive. The remaining 65 (70.56%) samples were found to be Negative for CMV IgM assay. 15 (16.3%) samples were found to be positive and 77 (83.6%) samples were negative for EBV IgM assay.

Keywords: CMV; EBV; IgM ELISA; SLE

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