ISSN: 2689-8020
Authors: El Mahfoudi A*, Lkhmaisse A, Zanane N and Hassouni K
Introduction: Mesenchymal chondrosarcoma (MC) is a rare variant of chondrosarcoma (CS) that accounts for up to 3- 10% of all CS. The head and neck localization is rare and may involve the sinonasal tract, jaws, larynx or skull base. It has been described as an aggressive neoplasm with high tendency for recurrences and delayed metastasis. Case report: We reported a case of a 41-years-old women complaining of right facial pain. Examination revealed hemorrhagic mass with bucco-palatal extension and causing displacement upper 2nd premolar teeth. Computed tomography (CT) scan revealed a lytic tumor arising of the left maxillary bone and extending into the orbit and the infratemporal fossae. Transoral biopsy was performed according to Caldwell luc technique. Histological examination and immunohistological study confirmed the diagnosis of high grade MC .Since the tumor was unresectable, the treatment was definitive concomitant chemoradiation (CCR) at the dose of 64Gy over 46 days by intensity modulation radiation therapy (IMRT), with a good response. The patient remains free of disease 12 months after treatment. After that she had a recurrent non metastatic disease, Combination chemotherapy with vincristine, doxorubicin, cyclophosphamide, ifosfamide, Mesna and etoposide was administered. Conclusion: MC of the sinonasal tract is an aggressive tumor with a predilection for young women. Recurrences develops in approximately one-third of patients and seems to predict a poor prognosis. Multimodal treatment based on surgery radiation and chemotherapy appears to improve clinical outcome.
Keywords: Mesenchymateous Chondrosarcoma Sarcoma; Radiation Therapy; Chemotherapy; Rare; Head and Neck; IMRT
