ISSN: 2640-2653
Authors: Tania Rahman*
In rodents, a combination of innate and adaptive immune responses is critical in controlling infection. The adaptive immune components, comprising B cells, CD4 T cells, CD8 T cells, pathogen specific secretory antibodies, and Treg cells have been exhibited to play an indispensable role in comprising and eliminating various infections. Also, there are several innate immune components that help to control infections, such as soluble mediators, lymphotoxin (LT) signaling in innate epithelial cells, TLRs, signaling adaptor MyD88, inflammasomes, CXCL9, P-selectin glycoprotein ligand-1 (PSGL-1). Little is known about the molecules that mediate the crosstalk between innate and adaptive immune response during infection. The work presented here has unravelled the potential of plasmacytoid dendritic cells (pDC) in the immune system in providing the first line of defense during natural infection as well as subsequent adaptive host defense against pathogens. In this work the potential that pDC might have in infection has been investigated in order to understand the basis of the development of protective and pathological responses during infection. These findings would help set up future avenues of research to elucidate a key mechanism of action of these cells and provide new therapeutic insights.
Keywords: Type I IFN-producing Cells, CD4 T Cells, CD8 T Cell, Treg Cell, Th17 Response, NK Cell, Soluble Mediators, Secretory Antibodies
