Differentiation of Myeloid Cell Precursors in Activated Gene-Engineered Dendritic Cells with Anti-Malignant Properties

Authors: Iskra VS

Volume 5, Issue 1

Abstract

Studies on the biology of dendritic cells (DCs) are mainly focused on their role as immune activators and modulators. In their appropriate cultivation and/or modifications, they have shown abilities for an enhanced expression of specific effective molecules. These cells have also been characterized as powerful antigen-presenting cells (APCs), including in composition of anti-malignant vaccines and gene-engineering products. By appropriate cultivation and/or modifications of DCs, they have shown abilities for enhanced expression of specific molecules. These properties have characterized them as promising candidates for construction of novel safe vaccines and gene-engineering products on their basis. In this aspect, in the last years the attention is directed to development of new safe therapeutic methods and techniques with DCs.

Keywords: Dendritic Cells (Dcs); Stem/Progenitor Cells; Myeloid Cell Differentiation; Recombinant Viral Vectors

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