ISSN: 2578-4641
Authors: Kulvinder Kochar Kaur*, Allahbadia G and Mandeep Singh
Earlier we have emphasized the role of gut microbiota in human health and role of dysbiosis in obesity, metabolic syndrome as well as non-alcoholic fatty acid liver disease (NAFLD). Further how they are involved in inflammatory signaling in the gut is already under publication, regarding how at various levels of intestines these bacilli might be influencing the development of systemic inflammation in obesity along with enterohepatic circulation with roles of bacteria associated with diets like high protein diet. It is realized that gut dysbiosis might correlate with umpteen diseases like as inflammatory bowel disease (IBD), Ulcerative colitis, Crohns disease, cardiovascular disease (CVD) as well as neurodegenerative diseases as well as cancers. Greater insight into gut microbiome, use of probiotic bacteria for the manipulation of gut microbiota for avoidance as well as treating a lot of diseases has gained a lot of attention. With the continuous formation of tools as well as technology, engineering probiotic microbes having wanted properties as well as functions for the benefit of human health has made considerable advances. Here we have tried to conduct a systematic review of utilizing them for diagnosing as well as treating various bacterial infections, role in certain metabolic disorders like type 1 diabetes mellitus (T1DM), Phenylketonuria (PKU), Hyperammonemia, neurodegenerative disease s like Parkinson’s disease, alzheimers disease along with specific severe infectious diseases like cholera, etc. associated with considerable mortality with probiotics having live bacteria for those specific purposes specifically engineered.
Keywords: Gut microbiota; Probiotics; Engineering probiotics; IBD; T1DM; PKU
