ISSN: 2574-7797
Authors: Trivedi D and Jana S*
Resveratrol is a natural polyphenol compound found in some plants and fruits that believed to be effective in improving overall health. The biological activity of resveratrol is limited by its poor absorption and first-pass metabolism that lead to having very low plasma concentrations following oral administration. Therefore, the current study was performed to determine the effects of the Trivedi Effect®-Energy of Consciousness Treatment for about 3 minutes by a renowned Biofield Energy Healer, Dahryn Trivedi, on resveratrol and rats through the measurement of plasma concentrations after a single oral dose administration of resveratrol. The test item, resveratrol was divided into two parts. One part was denoted as the control, while the other part was defined as the Biofield Energy Treated sample. Additionally, one group of animals also received Biofield Energy Treatment under similar conditions. The Biofield Energy Healer who was located in the USA, while the test samples and animals were located in the research laboratory in India. Resveratrol oral formulations were administrated by oral gavage at a dose of 100 mg/kg in groups viz. G1 (untreated resveratrol), G2 (Biofield Treated resveratrol) and G3 (Biofield Treated animals received untreated resveratrol) group. The results showed that maximum concentration (Cmax) of resveratrol was significantly increased by 185.98% and 108.82% in the G2 and G3 groups, respectively, compared with the G1 group. The relative oral exposure (AUC0 –t) of resveratrol was increased by 148.02% in the G2 group and decreased by 4.34% in G3, as compared to the G1 group. The time to reach peak concentration (Tmax) of resveratrol was significantly increased by 168% in the group G2 and 68% in the group G3 compared to the group G1. The oral bioavailability (F) of resveratrol was significantly increased by 147.75% in the G2 group and slightly decreased by 4.49% in the G3 group compared to the untreated resveratrol group. These data demonstrated an improved oral bioavailability of Biofield Energy Treated resveratrol might be helpful to prevent/cure many diseases. Hence, Biofield Energy Treatment could be considered as an innovative strategy that opens new avenues to overcome poorly absorbed nutraceuticals/pharmaceuticals and can also improve the therapeutic performance of orally bioactive molecules.
Keywords: Resveratrol; Biofield Energy Treatment; Pharmacokinetics; Bioavailability; LC-MS-MS; Rat
