Covid-19 Breakthrough Infections in Vaccinated People. A Clinical-Epidemiological Case Series Reporting of 30 Patients in Toledo (Spain) from February to September 2021

Authors: Turabian JL*

DOI: 10.23880/eij-16000208

Volume 5, Issue 4

Abstract

Background: COVID-19 vaccines show excellent efficacy, but some people still become infected with SARS-CoV-2 after vaccination. Objective: To study, in general medicine, COVID-19 breakthrough infections in vaccinated people Methodology: An observational, longitudinal and prospective case series study of COVID-19 breakthrough infections in vaccinated people, based on a prospective cohort of patients was carried out from February 1, 2021 to September 30, 2021, in a general medicine office in Toledo (Spain) Results: During the 8 months of the study, 30 patients with COVID-19 breakthrough infections in vaccinated people were included, with a mean age of 65 years. 53% were women. 73% were symptomatic. Mild symptoms of ENT predominated (33%), followed by respiratory (27%). 57% had chronic diseases. 60% of the cases had been vaccinated with BNT162b2 mRNA vaccine (Comirnaty, Pfizer/BioNTech) and 20% with ChAdOx1 nCoV-19 vaccine (Vaxzevria, Oxford / AstraZeneca). Conclusion: In the context of general medicine in Toledo (Spain), during the first 8 months of COVID-19 vaccination, COVID-19 breakthrough infections in vaccinated people occur in older adults with chronic diseases, without gender differences, and frequently they are mild symptomatic. Each of the vaccines has associated breakthrough infections.

Keywords: COVID-19; SARS-CoV-2; Vaccination; Breakthrough Infection; General Practice; Case Series

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