Novel Cefixime Loaded Citric Acid Dendrimer for Antibacterial Activity Against Pseudomonas Aeruginosa and Staphylococcus Aureus

Authors:

Ramadoss k^1*, MadhuSudhan RA¹ and Oruganti SK²

DOI: 10.23880/nnoa-16000102

Volume 1, Issue 1

Abstract

The principle goal of the study is to blend third era of citrus extract dendrimer and by connecting polyethylene glycol for diminishing systemic poisonous quality which is non-particular and to give delayed release of the drug called Cefixime by expanding the dissemination time of the drug and additionally framework to hinder resistance delivering strains Pseudomonas aeruginosa and Staphylococcus aureus. For safe and specific focusing of drug into the cells without damage of normal blood cells was finished by entrapment of Cefixime drug into the PEGylated dendrimer. The drug loaded formulations was assessed for their in-vitro release studies and physicochemical properties. To ensure efficacy and safety, additionally improved formulations have to be assessed for antibacterial activity and toxicity. This study demonstrated huge delayed release of Cefixime contrasted and non-PEGylated dendrimeric framework.

Keywords:

Novel Drug Delivery; Citric Acid Dendrimer; Pegylation; Cefixime

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