ISSN: 2474-9230
Authors: Arzoo S*
Pre-implantation genetic diagnosis (PIGD) is the genetic profiling of the embryos prior to implantation and sometimes even of oocytes prior to fertilization. PGD is considered in a similar fashion to prenatal diagnosis. Initially offered for diagnosis in couples at risk for single gene genetic disorders, such as cystic fibrosis, spinal muscular atrophy and Huntington’s disease, preimplantation genetic diagnosis (PGD) has most frequently been employed in assisted reproduction for detection of chromosome aneuploidy from advancing maternal age or structural chromosome rearrangements. Major improvements have been seen in PGD analysis with movement away from older, less effective technologies, such as fluorescence in situ hybridization (FISH), to newer molecular tools, such as DNA microarrays and next generation sequencing. Discussions regarding the scientific, ethical, legal and social issues surrounding the use of sequence data from embryo biopsy have begun and must continue to avoid concern regarding eugenic or inappropriate use of this technology.
Keywords: Pre-implantation Genetic Diagnosis; Inherited Genetic Disorders
