Medwin Publishers

Discover Research Beta

Browse peer-reviewed articles from Medwin Publishers' open access journals.

Clear Filters

Showing 1–4 of 4 articles

"Hasegawa A" ×
ACT Research Article Feb 13, 2023
How Bulky of Base Adducts can be Responsible for Clastogenicity rather than Mutagenicity?
Kikuchi Y, Galbreath HE, Kobayashi R, Kudou S, Matsumoto K, Hasegawa A, Saito T, Sato K, Honma T, Yamamoto A, Arai H, Kadoma Y, Kawaguchi S, Furuya K, Kobune M, Nakamura T and Yu F Sasaki*

Two types of TK mutants are induced by genotoxic factors; normally growing (NG) TK mutants due to point mutations of targeted TK locus, and slowly growing (SG) mutants due to gros…

Bulky adducts n-Alkyl methanesulfonates Slowly growing TK mutant
Full Text PDF Read Article
ACT Research Article Dec 1, 2021
Is Genotoxicity of Peroxisome Proliferator-Activated Receptor Agonists Due to Oxidative Stress Via Agonistic Pathways?
Kojima H, Nakamura T, Matsumoto K, Hasegawa A, Saito T, Sato K, Honma T, Yamamoto A, Arai H, Kadoma Y, Kawaguchi S, Kikuchi Y and Sasaki YF*

In order to investigate the relationship between genotoxicity and peroxisome proliferator-activated receptor (PPAR) agonistic effects, we conducted two kinds of comet assays (cell…

PPAR Agonist PPAR Antagonist Genotoxicity
Full Text PDF Read Article
ACT Research Article Jun 10, 2022
Are Bases Alkylated by Branched Alkylating Agents Removed by Nucleotide Excision Repair or Base Excision Repair?
Kotaro Sasaki, Runa Kobayashi, Takanori Nakamura, Yasuaki Kikuchi, Galbreath Hannah Elizabeth, Katsutoshi Matsumoto, Akira Hasegawa, Takayuki Saito, Kumiko Sato, Tetsuo Honma, Ayumi Yamamoto, Hirotada Arai, Yoshihiro Kadoma, Satomi Kawaguchi, Kazuyuki Furuya, Marina Kobune and Yu F Sasaki*

We have shown that comet-positive responses by adducts that are repaired by nucleotide excision repair (NER) and base excision repair (BER) are reduced by α-amanitin (AMN) and enh…

mation of Comet Tails NER BER
Full Text PDF Read Article
NNOA Research Article May 25, 2018
Efficiencies of the Cryoprotectants N-Methylacetamide, N-Methylformamide and Dimethyl Sulfoxide, and the Cell Protectants Trehalose and Hydroxyethyl Starch in Cryopreservation of Swine Sperm
Osuga T1*, Hasegawa T2, Aoki M1, Fujie M3, Nakane T2 and Asai T4

Polar molecules protect against freeze-induced damage by interfering with the polarised water arrangement during ice nucleation inside cells. Insufficient protection from freeze-in…

Freeze-induced damage Cryopreservative-induced cytotoxicity Cell permeation
Full Text PDF Read Article