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ACT Research Article Nov 25, 2025
Re-Evaluation of the Genotoxicity of Currently Used Food Dyes in Mouse Multiple Organs Via Continuous Administration by Drinking Using the Comet Assay
Yokohama N, Zenke A, Kawaguchi S, Nakamura T, Ymamoto A, Saito T, Kadoma Y and Yu F Sasaki

Among currently used food dyes, we have reported that four azo dye and three xanthene dyes that were given to mice by single gavage at a low dose (10 or 100 mg/kg) induced DNA dama…

Food Dyes Mouse GI-Tract
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ACT Research Article Dec 1, 2021
Is Genotoxicity of Peroxisome Proliferator-Activated Receptor Agonists Due to Oxidative Stress Via Agonistic Pathways?
Kojima H, Nakamura T, Matsumoto K, Hasegawa A, Saito T, Sato K, Honma T, Yamamoto A, Arai H, Kadoma Y, Kawaguchi S, Kikuchi Y and Sasaki YF*

In order to investigate the relationship between genotoxicity and peroxisome proliferator-activated receptor (PPAR) agonistic effects, we conducted two kinds of comet assays (cell…

PPAR Agonist PPAR Antagonist Genotoxicity
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ACT Research Article Feb 13, 2023
How Bulky of Base Adducts can be Responsible for Clastogenicity rather than Mutagenicity?
Kikuchi Y, Galbreath HE, Kobayashi R, Kudou S, Matsumoto K, Hasegawa A, Saito T, Sato K, Honma T, Yamamoto A, Arai H, Kadoma Y, Kawaguchi S, Furuya K, Kobune M, Nakamura T and Yu F Sasaki*

Two types of TK mutants are induced by genotoxic factors; normally growing (NG) TK mutants due to point mutations of targeted TK locus, and slowly growing (SG) mutants due to gros…

Bulky adducts n-Alkyl methanesulfonates Slowly growing TK mutant
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ACT Research Article Jun 10, 2022
Are Bases Alkylated by Branched Alkylating Agents Removed by Nucleotide Excision Repair or Base Excision Repair?
Kotaro Sasaki, Runa Kobayashi, Takanori Nakamura, Yasuaki Kikuchi, Galbreath Hannah Elizabeth, Katsutoshi Matsumoto, Akira Hasegawa, Takayuki Saito, Kumiko Sato, Tetsuo Honma, Ayumi Yamamoto, Hirotada Arai, Yoshihiro Kadoma, Satomi Kawaguchi, Kazuyuki Furuya, Marina Kobune and Yu F Sasaki*

We have shown that comet-positive responses by adducts that are repaired by nucleotide excision repair (NER) and base excision repair (BER) are reduced by α-amanitin (AMN) and enh…

mation of Comet Tails NER BER
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