Open Access Journal of Pulmonary & Respiratory Sciences
Research Article
1 min read
Alpha-1 Antitrypsin Genotypes in Patients with Chronic Obstructive Pulmonary Disease
Keywords
Alpha-1 Antitrypsin
Genotypes
Chronic
Obstructive
Pulmonary Disease
Abstract
Alpha-1 antitrypsin (AAT), a proteinase inhibitor produced by the SERPINA1 gene that protects the pulmonary alveoli and other connective tissues in the lungs against the destructive effects of neutrophil elastase and other proteases. SERPINA gene is known to be associated with COPD. The main evidence of this is the development of pulmonary emphysema in humans.
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