Herbs as Antidepressants: A Review

Yousuf Rather J*, Younis Raja W, Ahmad Dar M, Gani R and Bhat AZ

Sciences University Of Kashmir, India, Tel: 9149432373; Email:

junaid.scholar@kashmiruniversity.net which is cited in this article.

Keywords: Plants; Anti-Depressants; Mania

Introduction

Disorders of mood or affect have been described since the 4th century BC. Despite this early acknowledgment, their etiology is still a source of debate. It can be primarily characterized as an illness with emotional symptoms such as anxiety and vegetative symptoms such as sleep disturbances, as per the report of world health organization 45 million are suffering from Behavioral or mental disorders which amounts to 12% of the global burden of the disease and is expected to rise to 20% by 2020 [1]. Depressions can be acute or chronic, depressive symptoms commonly include emotional and biological components. Biological symptoms include retardation of thought or action loss of libido, sleep disturbances and appetite loss, symptoms of emotional components include misery, apathy pessimism, and low self-esteem, consistently feeling of guilt, Inadequacy, Ugliness and loss of motivation [2]. The clinical status of depressed patients, over time, has been is generally described by four terms (Remission, Recovery, Relapse, Recurrence_,) as roughly ‘4_ Rs’ of depression. Remission refers to the swinging cum restoration to normalcy after lasting for 2 months. Recovery similar term related to Remission but the improvement should have lasted for more than 2 months. The term Relapse means returning from the depressive episode within 2 months of improvement, on the other hand if depressive episode occurs after 2 months of improvement it is termed as Recurrence [3, 4, 5, 6, 7, 8, 9, 10].

Depression is one of the diseases which are spreading fast affecting the person from all the age groups, Most commonly found now days in the Age group between 10- 30years. Children’s are also mostly affected now a day because of fare of going school, exam burden and other problems keeping them involved in different bad hobbits such as Smoking etc [11, 12, 13, 14, 15, 16, 17, 18, 19, 20].

Although plenty of pharmaceutical agents are available for the treatment of mood disorders, anxiety, insomnia, many patients have difficulty tolerating the side effects, do not respond adequately, or eventually lose their response and there high costs making it difficult for the common man to go for allopathic treatment of any disease [21, 22, 23, 24, 25]. Many Medicinal plants with very less side effects have been discovered which may provide an alternative treatment or can be used to enhance the effect of prescription medications. Among them are the plants which are given below [25, 26, 27, 28, 29, 30, 31, 32]. Material and Methods In this review the data for the preparation of the manuscript was collected using the keywords medicinal

Results

plants_,_ Anti-depressants, Plants as anti-depressants, FST, TST, which were entered in to the international database of web knowledge comprising of PubMed, Scopus, and Google scholar [33, 34, 35, 36, 37, 38, 39, 40]. The articles published from 2015 to till date demonstrating Anti-depressant activity of plants were selected. The plants were arranged in tabular form with their families, part of the plant used, solvent used for the preparation of extracts, dosage of the extracts used in extracts used in animals, model used for evaluating the behavioral changes and reference drug used (Table 1).

Table 1: Model Used for Evaluating the Behavioral Changes and Reference Drug Used. Conclusion Plants have played a vital role in management of human health since the evolution. Medicinal plants exerts great role in discovery of new drugs. Majority of human population worldwide is getting affected by mental disorders. Many of them have been studied scientifically and proved to be beneficial Anti-depressant agents. 58 plant species belonging to different families have been reported to possess Anti-depressant activity from the Beginning of 2015 till date out of them prominent amoung them are Lamiaceae ,Fabiaceae, Asteraceae and methanolic extract found to be more dominant [51, 52, 53, 54, 55, 56, 57, 58]. The active compounds of these plants need to be isolated by proper method of isolation so that these plants can be explored clinically. References

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