Role of turmeric with Calcium Hydroxide in Combination in Prophylaxis & Therapeutic Management of SARs Cov2 Covid-19 Corona Virus

Introduction

Covid-19 corona virus (SARs-Cov2) that is severe acute respiratory syndrome. Despite worldwide efforts, the pandemic is continuing so there is utmost need of clinically proven prophylaxis and therapeutic management. Right know there is no treatment or medicine has only evidence- based treatment for covid-19. Hence there is utmost need of clinical intervention by ancient traditional health science that is Ayurveda.

In Ayurveda text ‘Acharya charaka has described in

‘vimansthan’ in ‘janpadodhawansan’ (epidemic) Chapter about causative factors and its management. It can also be correlated with the disease called ‘Tiwra Pinas’ which is a disease of respiratory tract having similar symptoms like SARs Cov2. This disease is ‘vata-Kaphapradhan sannipataj jwar’ for this most of the medicines advocated are ‘aagneya in guna’ which may break the chain of virus and treat the disease [1, 2].

The coronavirus is RNA virus (ribo nucleic acid). This virus is not living organism but protein molecule covered in protective layer of lipid (fat), which, when absorbed by the cells of ocular, nasal ,buccal mucosa the virus changes his genetic code (mutation) and converts into the aggressive and multiplier cells. As it are not bacteria, so no antibiotic works in this disease at primary level. The vaccines (when it will be developed) will be for prevention and not treatment of existing disease.

There are some Ayurvedic prophylaxis and therapeutic measures, which may be helpful in breaking the virus and treating the disease which will reduce mortality rate. In prophylaxis management the main role of immunity booster is to form the antibodies against the virus. In covid-19 complications other than pneumonia there may be disseminated intravascular coagulation (thrombosis). The affected parts are lungs & terminally cardiac arrest, stroke and many other thrombo-embolic diseases which may mainly cause pulmonary thrombosis (thrombo-embolism) [3].

The role of calcium hydroxide with turmeric powder extract may be very helpful in prophylaxis and therapeutic management of SARs Cov2 covid-19 corona virus.

Materials

Turmeric is a spice that has received much interest from both the medical/scientific worlds as well as from the culinary world. Turmeric is a rhizomatous herbaceous perennial plant (Curcuma longa) of the ginger family. The medicinal properties of turmeric, the source of curcumin, have been known for thousands of years; however, the ability to determine the exact mechanism(s) of action and to determine the bioactive components has only recently been investigated]. Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5- dione), also called diferuloylmethane, is the main natural polyphenol found in the rhizome of Curcuma longa (turmeric) and in others Curcuma spp. Curcuma longa has been traditionally used in Asian countries as a medical herb due to its antioxidant, anti-inflammatory [4], anti-mutagenic, antimicrobial , and anticancer properties.

Curcumin, a polyphenol, has been shown to target multiple signalling molecules while also demonstrating activity at the cellular level, which has helped to support its multiple health benefits. It has been shown to benefit inflammatory conditions, metabolic syndrome, pain, and to help in the management of inflammatory and degenerative eye conditions. In addition, it has been shown to benefit the kidneys. While there appear to be countless therapeutic benefits to curcumin supplementation, most of these benefits are due to its antioxidant and anti-inflammatory effects. Despite its reported benefits via inflammatory and antioxidant mechanisms, one of the major problems with ingesting curcumin by itself is its poor bioavailability which appears to be primarily due to poor absorption, rapid metabolism,  and rapid elimination. Several agents have been tested to improve curcumin’s bioavailability by addressing these various mechanisms. Most of them have been developed to block the metabolic pathway of curcumin in order to increase its bioavailability. For example, piperine, a known bioavailability enhancer, is the major active component of black pepper and is associated with an increase of 2000% in the bioavailability of curcumin. Therefore, the issue of poor bioavailability appears to be resolved by adding agents such as piperine that enhance bioavailability, thus creating a curcumin complex. Curcumin is being recognized and used worldwide in many different forms for multiple potential health benefits. For example, in India, turmeric-containing curcumin-has been used in curries; in Japan, it is served in tea; in Thailand, it is used in cosmetics; in China, it is used as a colorant; in Korea, it is served in drinks; in Malaysia, it is used as an antiseptic; in Pakistan, it is used as an anti- inflammatory agent; and in the United States, it is used in mustard sauce, cheese, butter, and chips, as a preservative and a coloring agent, in addition to capsules and powder forms. Curcumin is available in several forms including capsules, tablets, ointments, energy drinks, soaps, and cosmetics. Curcuminoids have been approved by the US Food and Drug Administration (FDA) as “Generally Recognized as Safe” (GRAS), and good tolerability and safety profiles have been shown by clinical trials, even at doses between 4000 and 8000 mg/day and of doses up to 12,000 mg/day of 95% concentration of three curcuminoids: curcumin, bisdemethoxycurcumin, and demethoxycurcumin [5].

Discussion

Probable role of calcium hydroxide with turmeric powder in prophylaxis & therapeutic management of SARs CoV2 covid-19 corona virus

In this viral infection the most affected part is respiratory tract by developing pneumonia secondary complications by developing thrombosis, embolism which terminally leads to ischemic heart/brain disease. The ischemia causes due to less oxygen supplied (hypoxia) to heart and brain. In this viral infection corona virus produces oxygen radicals in large amount, which affects the functioning of lungs and secondly other organs. The combination of calcium hydroxide with turmeric powder extract blocks uric acid and oxygen radical production from purines that are formed by the body. Turmeric is anti-hyperuricemic agent which may be effective in ischemia and congestive cardiac failure.

As curcumin is antiviral in combination with calcium hydroxide, its potency as antiviral increases. As the pH of calcium hydroxide is 12.4 is highly alkaline, it also acts as immunomodulator. The turmeric is known as immunomodulator, so in combination the action increases, so they jointly form antibodies against corona virus. Turmeric is anticoagulant, so it may act as anticoagulant which prevents thrombosis, embolism. Turmeric is broad- spectrum inhibitor. It is also cardio-protective, natural antibiotic, strengthens overall energy, works in breathless and mucus formed in throat.

As per Ayurveda turmeric reduces “kapha ’ and so it removes mucus from throat .It also alleviate cough Curcumin deoxifies blood which helps to remove toxins from body as it is having anti-inflammatory effect, it reduces inflammation in throat and lungs Turmeric is antagonistic increases HDL, natural antibiotic, anti-parasitic, antibacterial, antifungal. Calcium hydroxide and curcuma exhibited the antiviral activity may reduces viral RNA expression protein synthesis and viral titre in addition it may have protective effect on cells against virus induced adapt apoptosis and cytopathic activity.

This combination inhibits replication of virus by inhibiting viral binding at the cell surface viral replication tool or suppression of cellular signalling pathway essential viral replication such as PI3K,AKT, NF-KB immune. This combination improves cognitive ability to boost the absorption of proteins by the body this combination is powerful antioxidant. Antioxidant scavenge damaging particles in the body known as free radicals which damages cell membrane, temper DNA and even cause cell death Antioxidant can neutralize free damage they causes in additionally this combination of calcium hydroxide and turmeric powder extract reduces inflammation by lowering level of inflammatory enzymes (Cox2 and lox)in the body and stop platelets from clamping together to form thrombosis the combination of calcium hydroxide and turmeric powder as it is antioxidant, it increases antioxidant enzymes and inhibits peroxidation the recommended dose is 500mg twice a day empty stomach. So over all calcium hydroxide with turmeric. Powder extract may have major role as prophylaxis and therapeutic management in SARs Cov2 covid-19 corona virus.

Conclusion

The turmeric and calcium hydroxide in combination may play important role in prophylaxis and therapeutic management of SARs CoV2 covid-19 corona virus.